Synthesis of Analgesics. XIX. Antipyrine Derivatives. (6).
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概要
- 論文の詳細を見る
1) 4-Formylantipyrine (III), 4-acetylantipyrine (XVIII), and 1,2-diphenyl-3-methyl-4-formyl-(IV) and 1,2-diphenyl-3-methyl-4-acetyl-5-pyrazolone (XIX), when heated with sulfur in morpholine, yielded the corresponding compounds of morpholides (V, XX, VI, and XXI). These morpholides were submitted to hydrolysis with aqueous or alcoholic alkali and respectively gave 4-antipyrinecarboxlic acid (VII), 4-antipyrineacetic acid (XXII), 1,2-diphenyl-3-methyl-5-pyrazolone-4-carboxlic acid (VIII), and 1,2-diphenyl-3-methyl-5-pyrazolone-4-acetic acid (XXIII), each in a good yield. 2) 4-Antipyrinecarboxamide (XIII) was converted to 4-aminomethylantipyrine (XXIV) by lithium aluminum hydride. However, hydrogenation of N, N-dialkyl-4-antipyrine-carboxamides (XIV) and (XV) under similar conditions gave 4-formylantipyrine (III).
- 公益社団法人日本薬学会の論文
- 1958-08-15
著者
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高橋 酉蔵
Pharmaceutical Institute, Medical Faculty, University, of Kyoto, and Gifu College of Pharmacy
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兼松 顯
Institute Of Synthetic Organic Chemistry Faculty Of Pharmaceutical Sciences Kyushu University
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兼松 顕
Institute Of Applied Organic Chemistry Faculty Of Engineering Nagoya University
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兼松 顕
Pharmaceutical Institute, Medical Faculty, University of Kyoto
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高橋 酉蔵
Pharmaceutical Institute Medical Faculty University Of Kyoto And Gifu College Of Pharmacy
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