Studies on Pyrimidine Derivatives. I. Synthesis of Thiazolo [5,4-d]-pyrimidines and Related Compounds. (1).
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概要
- 論文の詳細を見る
The reaction of 2-chloro-4-thiocyano-5-nitropyrimidine with alcohol, sodium alkoxide, or sodium ethanethioxide was studied, and 5-nitrouracil, 2-ethoxy-4-mercapto-5-nitro-pyrimidine (IV), and 2-ethylthio-4-thiocyano-5-nitropyrimidine (VII) were obtained from the above reagents, while (IV) was reduced to the corresponding amino derivative (VIII). 2-Amino-5-ethylthio-thiazolo [5,4-d] pyrimidine was synthesized by the reduction of (VII). Treatment of (VIII) with formic acid, acetic anhydride, or potassium methylxanthate, gave 5-ethoxy-, 2-methyl-5-ethoxy-, and 2-mercapto-5-ethoxythiazolo [5,4-d] pyrimidine, respectively.
- 公益社団法人日本薬学会の論文
- 1958-08-15
著者
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高橋 酉蔵
Pharmaceutical Institute, Medical Faculty, University, of Kyoto, and Gifu College of Pharmacy
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井上 昭二
Pharmaceutical Faculty Nagoya City University
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内藤 多喜夫
Faculty of Pharmacy, Meijo University
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内藤 多喜夫
Pharmaceutical Faculty, Nagoya City University
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内藤 多喜夫
Faculty Of Pharmacy Meijo University
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高橋 酉蔵
Pharmaceutical Institute Medical Faculty University Of Kyoto And Gifu College Of Pharmacy
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