Studies on Pyrimidine Derivatives. VI. Synthesis of Thiazolo [5,4-d] pyrimidines and Related Compounds. (6).
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概要
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By treatment with hydrogen peroxide 2-methyl-7-mercaptothiazolo [5,4-d] pyrimidine was easily oxidized to the 7-hydroxy compound, and it was converted into the 7-chloro derivative. 7-Substituted (-OC_2H_5,-OC_6H_5,-NHC_2H_5 and -NHC_6H_5) 2-methylthiazolo-[5,4-d] pyrimidines were synthesized from 7-chloro-2-methylthiazolo [5,4-d] pyrimidine. 2,7-Dimercaptothiazolo [5,4-d] pyrimidine was prepared from 4,6-dimercapto-5-amino-pyrimidine and potassium methylxanthate. The heating of 4-mercapto-5-amino-6-benzylthio-pyrimidine (XII) with formic acid or phosgene also resulted in ring closure to afford 7-benzylthio-thiazolo [5,4-d] pyrimidine or 2-hydroxy-7-benzylthio-thiazolo [5,4-d]-pyrimidine (XIV). Cleavage of (XIV) with sodium hydroxide solution was examined and (XII), the starting material, was recovered by the liberation of CO_2.
- 公益社団法人日本薬学会の論文
- 1958-08-15
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関連論文
- Studies on Pyrimidine Derivatives. VII. Synthesis of Thiazolo [5,4-d] pyrimidines and Related Compounds. (7)
- Studies on Pyrimidine Derivatives. VI. Synthesis of Thiazolo [5,4-d] pyrimidines and Related Compounds. (6).
- Studies on Pyrimidine Derivatives. V. Synthesis of Thiazolo [5,4-d] pyrimidines and Related Compounds. (5).
- Studies on Pyrimidine Derivatives. IV. Synthesis of Thiazolo [5,4-d] pyrimidines and Related Compounds. (4).
- Studies on Pyrimidine Derivatives. III. Synthesis of Thiazolo [5,4-d] pyrimidines and Related Compounds. (3).
- Studies on Pyrimidine Derivatives. II. Synthesis of Thiazolo [5,4-d] pyrimidines and Related Compounds. (2).
- Studies on Pyrimidine Derivatives. I. Synthesis of Thiazolo [5,4-d]-pyrimidines and Related Compounds. (1).