Synthesis of Novel 2-Substituted-1,3,4-thiadiazoles
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概要
- 論文の詳細を見る
New 2-monosubstituted and 2,2-disubstituted 2,3-dihydro-3,5-diphenyl-1,3,4-thiadiazoles (2) were synthesized by the reaction of N'-phenylthiobenzoylhydrazide with aliphatic, aromatic and heterocyclic aldehydes and ketones in the presence of trimethylsilyl chloride in benzene. The reaction proceeded smoothly to afford the corresponding 1,3,4-thiadiazoles (2a-2j) in excellent yields (84-96%) except for a few cases, such as the 5-methyl-2-furfural and 2-acetylthiophene systems. 2,3-Dihydro-2,2-dimethyl-3,5-diphenyl-1,3,4-thiazole (2f) showed curative activity against powdery mildew of wheat.
- 公益社団法人日本薬学会の論文
- 1998-02-15
著者
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YAMAMOTO Takayuki
Department of Electronics, Faculty of Engineering, Tottori University
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Kitano Kazutada
Department Of Applied Chemistry Faculty Of Science And Engineering Kinki University
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MATSUBARA Yoshio
Department of Drug Safety Research, Eisai Co., Ltd.
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YUMOTO Takashi
Department of Electrical and Electronic Engineering, Faculty of Engineering, Tottori University
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MAESHIMA Toshihisa
Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
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Matsubara Yoshio
Department Of Applied Chemistry Faculty Of Science And Engineering Kinki University
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Yamamoto T
Department Of Applied Chemistry Faculty Of Science And Engineering Kinki University
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Maeshima T
Department Of Applied Chemistry Faculty Of Science And Engineering Kinki University
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Yamamoto Takayuki
Department Of Electronic Engineering Faculty Of Engineering Tohoku University
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Matsubara Y
Department Of Applied Chemistry Faculty Of Science And Engineering Kinki University
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YAMAMOTO Takayuki
Department of Communications and Integrated Systems, Tokyo Institute of Technology
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Yamamoto Takayuki
Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
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