γ-Pyrones from Gonystylus keithii, as New Inhibitors of Parathyroid Hormone (PTH)-Induced Ca Release from Neonatal Mouse Calvaria
スポンサーリンク
概要
- 論文の詳細を見る
New γ-pyrones, 9'-oxopodopyrone (3) and 8-methyl-9'-oxopodopyrone (4) were isolated from the leaves of Gonystylus keithii, along with known γ-pyrones, 10'-oxopodopyrone (1) and 8-methyl-10'-oxopodopyrone (2). These γ-pyrones markedly inhibited the bovine parathyroid hormone (PTH)-induced Ca release from neonatal mouse calvaria in vitro. It is the first time that γ-pyrones showed inhibitory effects on bone resorption, and these compounds may be seed compounds of new drugs for osteoporosis.
- 公益社団法人日本薬学会の論文
- 1997-06-15
著者
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NISHIZAWA MAKOTO
Hokkaido Institute of Public Health
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NISHIZAWA Makoto
Faculty of Bio-Industry, Tokyo University of Agriculture
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Nishizawa Makoto
Fac. Of Bio-industry Tokyo Univ. Of Agriculture
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Nishizawa Makoto
(present Address)kyosei Pharmaceutical Co. Ltd.
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Minobe Yasushi
Bio-medical Division Sumitomo Metal Industries Ltd.
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Kuda T
Ishikawa Agricultural Coll. Ishikawa Jpn
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KANAZAWA Tsutomu
(Present address)Amino Up Chemical Co., Ltd.,
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OHKAWA Yuki
Bio-Medical Division, Sumitomo Metal Industries, Ltd.,
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KUDA TAKASHI
(Present address)Ishikawa Agricultural Junior College
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TANI Tadato
Bio-Medical Division, Sumitomo Metal Industries, Ltd.,
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Ohkawa Y
Bio-medical Division Sumitomo Metal Industries Ltd.
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Kanazawa T
(present Address)amino Up Chemical Co. Ltd.
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Tani Tadato
Bio-medical Division Sumitomo Metal Industries Ltd.
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