Cytoplasm Prepared from All-trans Retinoic Acid (ATRA)-Treated Human Hematopoietic Progenitor Cells Induces Differentiation of Both ATRA Sensitive and ATRA Resistant Leukemia Cells (Toxicology)
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概要
- 論文の詳細を見る
In this study, hematopoietic cells from human placenta! Blood were treated with the differentiation-inducing drug all-trans retinoic acid (ATRA). Their cytoplasm was then used to culture the human myelogenous leukemia cell line HL60, NB_4 cells and the RA-resistant HL60-R and NB_4-R_2 cells. All of these four kinds of leukemia cells underwent macrophage/monocyte differentiation and apoptosis, while their proliferation was inhibited. This suggests that the RA receptors were not essentially needed in this situation, and this method should be applicable in the treatment of RA-resistant promyelocytic leukemia as well as other kinds of leukemia.
- 公益社団法人日本薬学会の論文
- 2004-04-01
著者
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Wang Z
Department Of Biological Sciences And Biotechnology Tsinghua University
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王 〓
Faculty Of Pharmaceutical Sciences Okayama University
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Wang Zhao
Department Of Biological Sciences And Biotechnology Tsinghua University
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ZHOU Jiangbing
Department of Biological Science and Biotechnology, Tsinghua University
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ZHANG Hongjun
Department of Biological Science and Biotechnology, Tsinghua University
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Wang Z
Faculty Of Pharmaceutical Sciences Okayama University
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Zhang H
Department Of Biological Sciences And Biotechnology Tsinghua University
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Zhou Jiangbing
Department Of Biological Sciences And Biotechnology Tsinghua University
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Wang Zhao
Protein Sci. Key Lab. Of The Ministry Of Education School Of Medicine Tsinghua Univ.
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WANG Zhao
Department of Anesthesiology, Northwestern University Medical School
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- Cytoplasm Prepared from All-trans Retinoic Acid (ATRA)-Treated Human Hematopoietic Progenitor Cells Induces Differentiation of Both ATRA Sensitive and ATRA Resistant Leukemia Cells (Toxicology)
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