Apoptosis Induced by Dioscin in Hela Cells
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概要
- 論文の詳細を見る
Dioscin, a saponin extracted from the root of Polygonatum Zanlanscianense Pamp, markedly inhibited proliferation of Hela cells. The results indicated that Hela cells underwent apoptosis in dose- and time-dependent manners when treated with Dioscin. Caspase-3, -8 and -9 activities were also detected. The low enzymatic activity of easpase-8 and high activity of caspase-9 showed that the mitochondrial pathway was activated in apoptosis. The reduced expression of the survival protein Bel-2 also confirmed this result. These studies may be significant in finding a new drug to treat human cervical cancer.
- 公益社団法人日本薬学会の論文
- 2002-02-01
著者
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Wang Z
Department Of Biological Sciences And Biotechnology Tsinghua University
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王 〓
Faculty Of Pharmaceutical Sciences Okayama University
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Wang Zhao
Department Of Biological Sciences And Biotechnology Tsinghua University
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JU Yong
Bioorganic Phosphorus Chemistry Laboratory, Tsinghua University
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LIU Mingjie
Department of Biological Science and Biotechnology, Tsinghua University
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Wang Z
Faculty Of Pharmaceutical Sciences Okayama University
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Ju Yong
Key Laboratory Of Bioorganic Phosphorus Chemistry Department Of Chemistry Tsinghua University
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Liu Mingjie
Department Of Biologcal Science And Biotechnology Tsinghua University
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CAl Jing
Department of Biologcal Science and Biotechnology, Tsinghua University
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Wang Zhao
Protein Sci. Key Lab. Of The Ministry Of Education School Of Medicine Tsinghua Univ.
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Cal Jing
Department Of Biologcal Science And Biotechnology Tsinghua University
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Cai Jing
Department Of Anatomy And Cell Biology The University Of Western Ontario
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WANG Zhao
Department of Anesthesiology, Northwestern University Medical School
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