Functions of a Chitosan-Orotic Acid Salt in the Gastrointestinal Tract
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概要
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A chitosan (CS)-orotic acid salt (CS-OT) was prepared, and the release of orotic acid (OT) from CS-OT as well as the adsorption of bile acids by CS-OT was investigated in vitro. The amount of OT released from CS-OT was about 2-2.7μmol/mg CS-OT and this changed depending on the species of CS. CS-OT also adsorbed bile acids and the amount increased increment ally according to the number of amino group contained in CS. Furthermore, CS-OT was given to rats as feed in order to investigate the influence on serum cholesterol levels. A decrease in serum cholesterol levels was observed in the group, which was fed a diet containing CS-OT or CS for 1-2 weeks, but no differences in body weight changes were recognized. Therefore, CS-OT may be applied to treating hyperlipidemia.
- 2003-05-01
著者
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Kojima N
Faculty Of Pharmaceutical Science Hokuriku University
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MURATA Yoshifumi
Faculty of Pharmaceutical Sciences, Hokuriku University
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Kawashima S
Faculty Of Pharmaceutical Science Hokuriku University
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Kawashima Susumu
Faculty Of Pharmaceutical Science Hokuriku University
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KOJIMA Naoko
Faculty of Pharmaceutical Science, Hokuriku University
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Murata Yoshifumi
Hokuriku Univ. Kanazawa Jpn
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Murata Yoshifumi
Faculty Of Pharmaceutical Science Hokuriku University
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Murata Yoshifumi
Faculty of Engineering Science, Osaka University
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