Properties of Calcium-Induced Gel Beads Prepared with Alginate and Hydrolysates
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概要
- 論文の詳細を見る
Calcium-induced alginate gel beads (Alg-Ca) containing alginate hydrolysate, such as the guluronic acid block (GB), was prepared and the drug release profiles were investigated under simulated gastrointestinal conditions. The addition of GB to Alg-Ca altered its rheological properties. A model drug (hydrocortisone) was incorporated at 78% of its theoretical yield within the dried Alg-Ca containing 5% GB and it was gradually released from the beads in JP XIV 1st medium for disintegration test (pH 1.2), while it was rapidly released with disintegration of the gel matrix in JP XIV 2nd medium (pH 6.8). In contrast, for Alg-Ca containing GB and chitosan, disintegration was not observed in these media and the drug release rate was markedly different. These results demonstrate that the release profiles of drugs incorporated into Alg-Ca can be controlled by adding these polysaccharides.
- 公益社団法人日本薬学会の論文
- 2004-05-01
著者
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Kawashima S
Faculty Of Pharmaceutical Science Hokuriku University
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KOFUJI Kyouko
Faculty of Pharmaceutical Science, Hokuriku University
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Kawashima Susumu
Faculty Of Pharmaceutical Science Hokuriku University
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Kofuji Kyoko
Hokuriku Univ. Kanazawa Jpn
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Murata Yoshifumi
Hokuriku Univ. Kanazawa Jpn
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Murata Yoshifumi
Faculty Of Pharmaceutical Science Hokuriku University
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JINNO Daisaku
Faculty of Pharmaceutical Science, Hokuriku University
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Jinno Daisaku
Faculty Of Pharmaceutical Science Hokuriku University
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Murata Yoshifumi
Faculty of Engineering Science, Osaka University
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