Functions of Chitosan-Ferulic Acid Salt for Prevention of Hypertension
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概要
- 論文の詳細を見る
A chitosan (CS)-ferulic acid (FA) salt was prepared. FA release from CS-FA and bile acid (BA) adsorption by CS-FA were investigated in vitro. CS-FA released FA into artificial gastric juice or a medium containing BA. Two functions were recognized on alginate or pectin gel beads containing CS-FA: FA release and BA adsorption. Anti-hypertensive effects of CS, FA or CS-FA on hypertensive rats were tested. In rats given a diet containing CS-FA or FA, elevation of systolic blood pressure was suppressed compared to the control diet group, but no difference in food intake or body weight was observed between groups.
- 2010-09-01
著者
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MURATA Yoshifumi
Faculty of Pharmaceutical Sciences, Hokuriku University
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Kofuji Kyoko
Faculty Of Pharmaceutical Science Hokuriku University
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Kishi Toshihiro
Nippon Suisan Ltd.
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NAGAKI Kumiko
Faculty of Pharmaceutical Science, Hokuriku University
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Murata Yoshifumi
Faculty Of Pharmaceutical Science Hokuriku University
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Nagaki Kumiko
Faculty Of Pharmaceutical Science Hokuriku University
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Murata Yoshifumi
Faculty of Engineering Science, Osaka University
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