Properties of an Alginate Gel Bead Containing a Chitosan-Drug Salt (Miscellaneous)
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概要
- 論文の詳細を見る
A calcium-induced alginate gel bead (Alg-CS) containing chitosan (CS) and 2- (4-chlorophenoxy) -2-methyl-propionic acid (CMP) was prepared. We then investigated (a) CMP release from Alg-CS, and (b) uptake of bile acid into the Alg-CS, within the gastrointestinal tract. Dried Alg-CS gradually swelled in taurocholate solution, while releasing CMP and taking up bile acid. The amount of bile acid taken up into the Alg-CS increased incrementally according to the degree of deacetylation of CS. Furthermore, the molecular weight of CS also affected the properties of the Alg-CS. An approximately linear relationship was observed between CMP release and bile acid uptake of Alg-CS.
- 公益社団法人日本薬学会の論文
- 2004-03-01
著者
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KAWASHIMA Susumu
Faculty of Pharmaceutical Sciences, Hokuriku University
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KOFUJI Kyoko
Faculty of Pharmaceutical Sciences, Hokuriku University
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MURATA Yoshifumi
Faculty of Pharmaceutical Sciences, Hokuriku University
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MIYAMOTO Etsuko
Faculty of Pharmaceutical Sciences, Hokuriku University
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Kofuji Kyoko
Faculty Of Pharmaceutical Science Hokuriku University
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Miyamoto E
Faculty Of Pharmaceutical Science Hokuriku University
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Kawashima S
Faculty Of Pharmaceutical Science Hokuriku University
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Miyamoto Etsuko
Faculty Of Pharmaceutical Science Hokuriku University
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HIRAI Daijirou
Faculty of Pharmaceutical Science, Hokuriku University
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Hirai Daijirou
Faculty Of Pharmaceutical Science Hokuriku University
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Kawashima Susumu
Faculty Of Pharmaceutical Science Hokuriku University
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Kofuji Kyoko
Hokuriku Univ. Kanazawa Jpn
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Murata Yoshifumi
Hokuriku Univ. Kanazawa Jpn
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Murata Yoshifumi
Faculty Of Pharmaceutical Science Hokuriku University
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Murata Yoshifumi
Faculty of Engineering Science, Osaka University
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