Properties of an Alginate Gel Bead Containing a Chitosan-Drug Salt (Miscellaneous)

概要

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A calcium-induced alginate gel bead (Alg-CS) containing chitosan (CS) and 2- (4-chlorophenoxy) -2-methyl-propionic acid (CMP) was prepared. We then investigated (a) CMP release from Alg-CS, and (b) uptake of bile acid into the Alg-CS, within the gastrointestinal tract. Dried Alg-CS gradually swelled in taurocholate solution, while releasing CMP and taking up bile acid. The amount of bile acid taken up into the Alg-CS increased incrementally according to the degree of deacetylation of CS. Furthermore, the molecular weight of CS also affected the properties of the Alg-CS. An approximately linear relationship was observed between CMP release and bile acid uptake of Alg-CS.
公益社団法人日本薬学会の論文
2004-03-01