Effects of Natural Polysaccharide Addition on Drug Release from Calcium-Induced Alginate Gel Beads
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概要
- 論文の詳細を見る
Calcium-induced alginate gel beads (Alg-Ca) containing various polysaccharides, including an alginate hydrolysate, were prepared and the drug release profiles were investigated. Hydrocortisone (HC) was gradually released from Alg-Ca into the mimic gastric fluid, while in intestinal fluid, it was quickly released with the dissolution of Alg-Ca. However, with Alg-Ca containing 5% chitin (CT), dissolution of Alg-Ca was not observed, and release of HC showed apparent zero-order kinetics. Furthermore, addition of the alginate hydrolysate altered the HC-released profile for Alg-Ca.
- 公益社団法人日本薬学会の論文
- 2003-02-01
著者
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Kofuji Kyoko
Faculty Of Pharmaceutical Science Hokuriku University
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Kawashima S
Faculty Of Pharmaceutical Science Hokuriku University
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Kawashima Susumu
Faculty Of Pharmaceutical Science Hokuriku University
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Kofuji Kyoko
Hokuriku Univ. Kanazawa Jpn
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Murata Yoshifumi
Hokuriku Univ. Kanazawa Jpn
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Murata Yoshifumi
Faculty Of Pharmaceutical Science Hokuriku University
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TSUMOTO Kumiko
Faculty of Pharmaceutical Science, Hokuriku University
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Tsumoto K
Faculty Of Pharmaceutical Science Hokuriku University
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Murata Yoshifumi
Faculty of Engineering Science, Osaka University
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