核医学検査における被検者の被ばく量低減の検討 : ^<99m>Tc-MDP について

概要

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^<99m>Tc-methylene diphosphonate (^<99m>Tc-MDP), which is excreted through the urinary tract and partly accumulated on the content of bladder, is the most common radiopharmaceutical form among the current bone scintigraphy. In order to find the methods decreasing the exposure of the whole body and the bladder, 15 patients were selected for the present study. Neither of them had renal disorder, nor demonstrated abnormal radionuclide increased uptake over the whole bones. They were divided into two groups; i. e 10 patients were forced to take fluid during examination and the other 5 patients were orderd not to take fluid. After administration of ^<99m>Tc-MDP, whole body activity was compared between these 2 groups. At the same time, exposure of patients' wall of the bladder was estimated from their urine activity. Forced fluid intake group received less radioactive exposure to the whole body than no fluid intake group did. For the forced fluid intake group, it is estimated that expousure of the wall of bladder can be reduced about 40% if one avoids urine in 50 minutes after administration of ^<99m>Tc-MDP insted of avoiding urine in 120 minutes.
公益社団法人日本放射線技術学会の論文
1992-10-01