慢性関節リウマチに対するアフェレシス療法

概要

論文の詳細を見る
Rheumatoid Arthritis is a chronic systemic articular inflammatory disorder of unknown etiology. Apheresis has been applied as one of the treatments. Apheresis techniques contain mainly two techniques, namely, plasmapheresis, which removes immune complex and autoantibodies, leukapheresis which removes activated granulocytes and/or lymphocytes. Plasmapheresis improves symptoms such as arthralgia, morning stiffness, grip strength, and walking time. Laboratorical findings such as erythrocyte sedimentation rate, macroglobulinemia and high levels of immune complex are also improved by plasmapheresis. Although leukapheresis also improves clinical signs and laboratorical data, the improvements appear relatively slowly compared with plasmapheresis. The indications of apheresis for the treatment of RA are 1) malignant rheumatoid arthritis (MRA) cases, 2) DMARD-resistant cases, 3) cases with high levels of immune complex, and 4) cases with the contraindication of a high close of steroids and/or NSAIDs.
日本アフェレシス学会の論文
1998-10-31