血管炎症候群に対するアフェレシス療法の位置づけ(厚生労働省研究班のガイドライン)(<特集>腎・血液領域の注目すべき疾患-アフェレシス療法のエビデンスとガイドライン-)

概要

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Vasculitis has been reported in virtually every organ and system, and it may cause many different clinical signs and symptoms. There are many types of vasculitis such as microscopic polyangitis, polyarteritis nodosa, allergic granulomatosis angiitis, and Wegener's granulomatosis. Some types of vasculitis have been associated with anti-neutrophil cytoplasmic antibody (ANCA), and they are sometimes called ANCA-related vasculitis. Although the underlying causes of systemic vasculitis are imperfectly understood, there have been significant advances in the clinical diagnosis of these disorders and their management. Because it sometimes causes serious organ damage such as irreversible renal failure and respiratory failure, fast and adequate medical intervention is necessary. Treatment for ANCA-related vasculitis has been studied under direction from the Ministry of Health, Labour and Welfare. Basic treatment for ANCA-related vasculitis is use of immuno-suppressive agents. Apheresis treatment is recommended to use in addition to the basic drug treatment when a patient has rapidly progressive glomerulonephritis or has both progressive renal and respiratory failure. This article describes types of ANCA-related vasculitis, and their recommended treatment including apheresis treatment. Types and problems of apheresis treatment are also discussed.
日本アフェレシス学会の論文
2006-02-28