腎移植と血漿交換療法

概要

論文の詳細を見る
Plasma exchange in the realm of kidney transplantation is indicated in the following three clinical situations : 1) ABO blood group type incompatibility, causing high circulating levels of anti-A and/or anti-B antibodles ; 2) high circulating levels of anti-T cell antibodies ; and 3) in the setting of focal glomerular sclerosis, where a 'vasculopermeability factor' responsible for renal glomerular protein loss results in the clinical manifestations of massive proteinuria. The obiective of plasma exchange is to remove these antibodies or pathogenic factors from the patients. Of the aforementioned clinical situations, only ABO blood group antigens and antibodies have been fully characterized and identified. The presence of anti-T cell antibody and a vasculopermeability factor are recognized, but have not been fully identified as of yet. At present, therefore, the effectiveness of plasma exchange for these latter two entities is varied. In this paper, we discuss plasma exchange in ABO-incompatible kidney transplantation, where its effectiveness is apparent.
日本アフェレシス学会の論文
1998-05-31