エンドトキシン吸着療法の有用性と問題点

概要

論文の詳細を見る
We evaluated the clinical characteristics of patients with endotoxin shock who showed an improvement of shock state, defined as 1) an increase in mean arterial pressure more than 10 mmHg or 25% or 2) decreases in the dose of vasopressors, during direct hemoperfusion using polymyxin B-immobilized fiber (PMX treatment). Out of 30 patients who received PMX treatment. 23 patients were diagnosed with endotoxin shock retrospectively. Eighteen out of the 23 patients showed an improvement of shock state during PMX treatment (E group). Age, white blood cell count, blood pressure and dose of vasopressor before PMX treatment were not different between the E group and non-E group. The E group was characterized by significantly lower cardiac index (CI). All of the patients who showed a CI from 2 to 6 L/min/m^2 survived. It is suggested that PMX treatment may be more effective for patients in mild hyperdynamic state than for those in a more severe hyperdynamic state.
日本アフェレシス学会の論文
1998-02-28