金製剤投与後のラット体内における金の挙動

概要

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The metabolism of gold in male rats was investigated over a period of 144 hours after single intraperitoneal injections of sodium aurothiomalate containing 12.1mg Au, a compound used in the treatment of rheumatoid arthritis. The amount of gold in blood serum and visceral organs was measured by flameless atomic absorption spectrometry using a carbon rod atomizer. It was found that there was a linear relationship between the concentration of gold (0-2.0ppm) and the absorbance with the detection limit for gold at 5×10-11g. Six hours after the injection, gold concentrations in serum had reached their highest levels, after which they decreased rapidly. Significant accumulations in the kidneys were found when compared to those recorded for the liver, lungs and spleen. Gold-treated rats had elevated blood urea nitrogen and serum creatinine concentrations as well as acute renal tubular necrosis. Therefore, it seems that kidney is one of the target organs of gold in this study.
日本衛生学会の論文