神経疾患に対する白血球系細胞除去療法 : 選択的に病因となるリンパ球を除去する試み(<特集>白血球系細胞除去療法の最近の展開)

概要

論文の詳細を見る
Antigen-specific CD 4^+ T cells play a central role in the pathogenesis of T cellmediated autoimmune diseases, such as multiple sclerosis (MS). To investigate the depletion of CD 4^+ T cells from the systemic circulation as an effective strategy for the treatment of MS, we performed extracorporeal CD 4^+ T cell adsorption, using a filter to which anti-CD 4^+ antibody is immobilized as a ligand, in adoptively transferred experimental autoimmune encephalomyelitis (EAE). Rats treated with a CD 4^+ T cell removal filter exhibited milder clinical signs of EAE and earlier recovery than those receiving sham treatment. Moreover, the thymic cells from EAE rats treated with the CD 4 removal filter exhibited a suppressed proliferative response to myelin basic protein. These results suggest that depletion of CD 4^+ T cells from the systemic circulation by extracorporeal treatment is a potentially useful strategy for treatment of T cell-mediated autoimmune disorders. Targeting other surface molecule, we can remove particular immune cells more selectively.
日本アフェレシス学会の論文
2005-05-31