DIFFERENTIATION OF MATRIX CELLS AND ITS HISTOCHEMICAL ASPECTS IN EARLY NEUROGENESIS (<Symposium>Contribution of Histochemistry to Developmental Neurobiology)

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We investigated the expression patterns of (1) intermediate filament proteins in the developing CNS according to the immunohistochemical and immunoblotting techniques and (2) glycosyl residues exposed on the cell membranes in the fetal brain using histochemical techniques. In the early neural tube which was composed of matrix cells (stage I), vimentin was found predominantly in the basal processes of these cells. After the beginning of neuron production (stage II), vimentin was present in "radial fibers", guideropes for migrating neuroblasts, which could be regarded as elongated basal processes of matrix cells. In this stage of neurogenesis, neurofilament protein was detected in the processes running parallel to radial fibers. These processes seemed to be those of migrating neuroblasts. Glial fibrillary acidic protein was detected for the first time after the cessation of neuron production (stage III). These results indicate the absence of glial cells in the early stages of neurogenesis (stages I and II). The lectin-histochemistry of the fetal brain implied the presence of abundant terminal sialyl and N-acetylglucosaminyl residues on the plasma membranes of various cells and fibers. On the other hand, it was suggested that terminal galactosyl residues on radial fibers are much fewer in the corticogenetic region than in the non-corticogenetic place. This difference in the amount of terminal galactosyl residues could be related to the mechanism of corticogenesis. A possible role of galactosyltransferase in this mechanism was suspected.
日本組織細胞化学会の論文

DIFFERENTIATION OF MATRIX CELLS AND ITS HISTOCHEMICAL ASPECTS IN EARLY NEUROGENESIS (<Symposium>Contribution of Histochemistry to Developmental Neurobiology)

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