老化と自己免疫疾患(<特集>老化とアフェレシス)

概要

論文の詳細を見る
Aging is associated with prgeressive decline in T-cell functions, including decreased response to mitogens, soluble antigens, and production of IL-2, along with a decrease in naive cells and an increase in memory cells. The age-related decline in thymic function causes extensive remodeling of the T-cell system. Age-dependent changes in T-cell homeostasis are accelerated in patients with autoimmune diseases. The immune system undergoes profound changes with advancing age that are beginning to be understood. These changes need to be incorporated into the pathogenetic models of autoimmune diseases. Activation-induced cell death (AICD) is a well-known mechanism of peripheral T-cell tolerance that depends upon an interaction between Fas and Fas ligand (FasL). Since activation of T-cell clones. or T-cell lines, induces FasL expression, and that interaction between Fas and its ligand is the major mechanism involved in AICD, a defect in AICD of effector T-cells may result in the development of age-related autoimmune diseases.
日本アフェレシス学会の論文
2004-05-31