腎および副腎疾患における腎中renin含量の測定 : とくに高血圧との関連を中心にして

概要

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Determination of renin in human kidneys obtained at operation of renal or adrenal diseases was carried out in more than 100 cases. Crude extract of human kidney acidified to pH 3.0 and incubated at 0℃ for 30 min. was used for renin preparations, which were practically free from angiotensinases. The pretreated renin preparation was reacted with human plasma at pH 6.5, 37℃, for 30 min., and angiotensin thus formed was bioassayed. The renin cantent was expressed in reaction constants (K) throughout this study. Renin content was increased in 3 of 4 cases with renovascular hypertension. In one case of malignant hypertension, normotensive aldosteronism, polycythemia with hypertension and renal artery stenosis, and acute ureteral stenosis with hypertension, the renin content was high. In hypertensive patients with adrenal orgin, such as primary aldosteronism, Cushing's syndrome, and pheochromocytoma, renin content decreased. In hydronephrotic kidneys, including the ones with ureteral stone, renin content seemed inversely proportional rather to renal damage than to arterial blood pressure. In tuberculous kidneys, uneven distribution of renin was proved. From these data, the relationship between renin content and arterial blood pressure was discussed. The author has suggested that renin was not a primary cause of hypertension.
社団法人日本泌尿器科学会の論文
1966-00-00