睾丸下垂体系の研究 : 第3報去勢及び性Hormone投与によるGonadotropinの変動について

概要

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The gonadotropin levels following castration, exogenous estrogen and testosterone administration were studied in human males. Serum LH and FSH levels were measured by radioimmunoassay in patients with prostatic cancer following castration and estrogen therapy. Effects of testosterone on gonadotropins were examined in patients with Klinefelter's syndrome receiving androgen replacement therapy. 1. After the castration, serum LH and FSH Ievels increased gradually in all six patients, and reached Ievels 3.5, 2.6 times higher than previous values at 7th postoperative day, respectively. 2. Administration of estrogen (Diethylstilbestrol diphosphate) suppressed both LH and FSH. FSH Ievels were more easily suppressed than LH Ievels. The doses of estrogen required to suppress the gonadotropins to the lowest level were about 30 to 60 mg/day for DES-diphosphate and 10 to 30 mg/day for Hexestrol. 3. By the administration of testosterone propionate (25-100 mg. im.), LH Ievels were markedly suppressed. FSH Ievels were also suppressed but not so marked as LH Ievels.
社団法人日本泌尿器科学会の論文
1974-12-20