思春期前男子の去勢がgonadotropin値に及ぼす影響について-思春期発来に関する考察

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The effects of prepubertal castration on circulating levels of LH and FSH were examined longitudinally in 3 male pseudohermaphrodites (1 yr., 6 yrs., 9 yrs.) and one Lt. monorchid (7 yrs.), and gonadotropin levels of prepubertal anorchism (9 yrs.) were also studied longitudinally.<BR>After castration, plasma LH and FSH concentration in the patient 1 yr. of age elevated significantly and progressively, but in two other patients 6 and 7 yrs. of age, a significant elevation of plasma LH and FSH was not observed from 90 to 450 days after the castration.<BR>Plasma LH and FSH concentration of one patient 9 yrs. of age, castrated at 1 yr., showed prepubertal values from 9 to 11 yrs. of age, and the abrupt elevation of LH and FSH occurred at 11-2/12 yrs. of age.<BR>From these observations we concluded that although castration in early childhood resulted in an immediate elevation of gonadotropin levels, a significant elevation of gonadotropin did not occur in midchildhood castration. These findings have also confirmed the evidence that the hypothalamic-pituitary-gonadal negative feedback mechanism is operative in early childhood, and supported the action of a CNS inhibitory mechanism which restrains the gonadotropin synthesis and secretion and inhibits puberty during the interval of midchildhood.
日本内分泌学会の論文