停留睾丸の内分泌学的研究 : 第1報 androgen biosynthesis (in vitro)における検体組織の微量化の検討

概要

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In order to evaluate the feasibility of utilizing small amount of testicular tissue for the studies of androgens biosynthesis in vitro, various amounts of testicular tissue from patients with carcinoma of prostate and with undescended testis were studied. The testicular tissues (0-100mg) were incubated with progesterone-7α-^3<H> and determinations of converted radioactive androgens were made. Between 0mg and 50mg of the testicular tissues, the conversion rate of progesterone to testosterone was proved to be propotional to the weight of the sample tissues. In conclusion, a 30mg sample of each testis was analysed to compare their ability of testosterone formation and interstitial cell function of various testicular tissues was estimated. The results indicated that studies of androgens biosynthesis of testis could be performed even with a small amount of testicular biopsy speciemen which was easily obtained without disturbing testicular function.
社団法人日本泌尿器科学会の論文
1976-10-20