抗生物質の腎蓄積性検討の新しい方式の試み

概要

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An analytical method was designed to assess the acculumation and toxicity of antibiotics to the kidney. Kidneys were homogenized and centrifuged for the cellular preparation. The supernatant fraction was mainly composed of cytoplasm and microsome, while lysosome and mitochondria were the main components or the sediment fraction. The antibiotic concentrations were separately measured in the elapse of time. Our experiments showed that high nephrotoxic agents such as Gentamicin and Tobramycin were found in the sediment fraction in all high conentration which was maintained for some time on the other hand a low concentration in the sediment fraction was noted on the administration of a low nephrotoxic substance. The present investigation revealed that hetacillin given to rats was found in a low concentration in the sediment, which declined promptly.
社団法人日本泌尿器科学会の論文