腎移植と抗Bリンパ球抗体 (その1) : 移植前血清と予後について

概要

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The pre-transplant serum samples from 38 living related renal transplant recipients were screened brcytotoxic antibodies against a panel of B and T lymphocyte at 4℃ and 37℃. The cytotoxicity positive sera were classified into three patterns: the T warm pattern which reacts with greater than 15% of T lymphocyte panel at 37℃; the B warm pattern which reacts with greater than 15% B lymphocyte panel and reacts less than 15% of T lymphocyte panel at 4℃ and 37℃; and the B cold pattern which reacts with greater than 15% of B lymphocyte at 4℃ and does not react under other conditions. According to the serum patterns, the patients were divided to four groups: T warm group, B warm group, B cold group and No antibodies group. The B cold group with history of blood transfusion had a higher graft survival rate than other groups. The B cold group without history of blood transfusion and B warm group did not have good grart survivals. The B cold cytotoxins as a product of blood transfusion seems to have an enhancing effects on living related kidney allografts.
社団法人日本泌尿器科学会の論文