結核菌の経歯感染に関する研究

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Seven healthy guinea pigs about 450 grams each in weight were served as test animals. Tuberculin reaction was negative in every animal. About I/150mg. of tubercle bacilli of human type were laid into the dental pulps of mandibular incisal teeth of each animal. The animals were killed after the lapse of one hour, one, five, ten, twenty, fifty, seventy days. Toda-hara's, Fontes', Campbell's staining method and Haematoxilineosin method were adopted. Decalcifying agent was five percent formic acid solution. The results were as follows. Tuberculous lesions were found in alveolar bone and its bone-marrow, in submaxillary lymphatic gland, in lymphatic glands of cervical region, lymphatic glands of hilus hepatis, in spleen and lung. We could stain tubercle bacilli in dental pulps, in periodontal membranes and in other organs. We could not find, however, the characteristic tuberculous lesion in any dental pulp examined. We presume that tubercle bacilli may pass through dental pulp, and form the tuberculous lesions anywhere throughout the organism,
1953-01-30