白鼠皮膚培養細胞におよぼす 5-Fluorouracil, Mitomycin C の影響について

概要

論文の詳細を見る
Generally, all of the antitumor agents which have been used in cancer chemotherapy inhibit selectively not only cancer cells but also normal cells adjacent to malignant tumor. As a result various side effects may occur. We carried out recently observation of effects on normal neonatal albino rat cells by explant culture method with antitumor agents (5-FU 5mcg/ml, MMC 0.4mcg/ml). It is the purpose of this paper to report effects on normal cells of antitumor agents from the standpoint of morphologic changes. The results obtained are as follows : 1) In 5-FU and MMC treatment, regressive degeneration of epithel like cells and fibroblast like ones was observed with the nuclei being affected first. Degree of degeneration in the latter was lower than that in the former. 2) As far as our observation was concerned, no significant difference between degenerative changes in cells due to 5-FU and those due to MMC was seen. 3) In dilantin sodium treatment a marked increase in fibroblast like cells was observed and different results from those of 5-FU and MMC were obtained. It was observed that many mitoses appeared to be abnormal division. 4) Excellent therapeutic results would be obtained if we determine, taking into consideration the side effects, dosage, administration time and frequency at the time of administration of the drugs.
九州歯科学会の論文
1969-07-31