制癌剤の感受性に関する研究 : 3. 制癌剤感受性試験としての I.N.K. 法、S.D.I. 法の一致性について

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For the selection of carcinostatic agents for clinical use, devising a useful susceptibility test has long been required. S.D.I. method as well as I.N.K. method as a susceptibility test there have been reports of Kondo et al., and Gomifuchi et al. Also in our Clinic S.D.I. and I.N.K. methods were followed as susceptibility tests, and the results summarized in Table (1-2) were obtained, using various carcinoma of the Oral and other regions which were removed from 35 patients who were operated upon at the Department of Second Oral Surgery, Kyushu Dental College and Kokura National Hospital. The data indicated that acording to S.D.I. method the most effective carcinostatic agent was Mitomycin C, and next Nitromin, Merphyrin, Toyomycin, Copp, Endoxan were arranged, according to I.N.K. method Mitomycin C, Toyomycin, Nitromin, Copp, Endoxan, and Merphyrin were arranged in order of the effectiveness. There was some difference in the order of the drugs in the two methods, but no remarkable difference in the rates of effectiveness. Therefore, attempting to increase the effect of the antineoplastic agents we investigated the coincidence of S.D.I. and I.N.K. methods in 16 clinical cases with various carcinoma, (including one sarcoma case) in which both methods were able to be carried out, among 35 cases above mentioned (Table 3). In this table (+) in S.D.I. method, (+) in I.N.K. method means "effective in both methods" and (-) means "non-effective in both". The data presented, in the order of the high coincidence of the carcinostatic agents. Copp, Endoxan, Toyomycin, Merphyrin, Mitomycin C, Nitromin. It is particularly important that the results of both methods coincide. The order of the effectiveness and the high coincidence of these drugs were Mitomycin C, Nitromin, Endoxan, Toyomycin, Merphyrin and Copp. A considerable difference between Mitomycin C with the highest effectiveness and Nitromin, the second, was observed. Our data was, however, obtained in vitro and it is doubtful if the results can also be applied in vivo. There is also another problem in the method itself in which the succinic dehydrogenase, the same system of the enzyme, was used both of S.D.I. and I.N.K. methods. Besides, the agents were applied to the cases before the test or not, and resistance against the agent caused by the administration for a long period of time, if any, were all neglected and the specimen obtained at operation was used for both of the examination, therefore, the difference of the results in vivo can not be denied. It should, however, be further examined how parallel the coincidence of S.D.I. and I.N.K. methods is to the clinical effect. For the first step of the solution of this problem, we investigated here on the coincidence of S.D.I. and I.N.K. methods.
九州歯科学会の論文
1966-12-31

制癌剤の感受性に関する研究 : 3. 制癌剤感受性試験としての I.N.K. 法、S.D.I. 法の一致性について

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