唇-顎-口蓋裂患者 100 症例の細胞遺伝学的研究

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The authors designed the chromosome studies on patients with the cleft lip and-palate to investigate its pathogenesis. On 100 patients of 25 cleft prepalate, 50 cleft prepalate and-palate and 25 cleft palate, chromosome studies were carried out by cultured peripheral blood leukocytes using a slight modification of the technique of Moorhead, et al. Out of 100 patients, 5 cases showed numeral or structural chromosome aberration ; one case D/E translocation, one case long No.1 chromosome, one case partial C trisomy (familial C/G transmission) and two cases 21 trisomy. And nine of the 55 male patients, consisted of 5 cases of cleft prepalate and 4 cases of cleft prepalate and palate patients had long Y sex chromosome. It is extremely interesting that 13 cases of the 14 patients with abnormal karyotype had the cleft of prepalate or its combined cleft in its cleft type.
九州歯科学会の論文
1970-05-31