THIOTHIAMINEの生物学的効力について : (V)THIAMINE, THIOTHIAMINE大量投与時の尿中排泄量

概要

論文の詳細を見る
Though thiothiamine and thiamine are much alike in chemical constitutions, thiothiamine is more easily absorbed from the intestines and its urinary excretion is much more than that of thiamine. Thiamine administered to albino rats on oral doses of 5-50mg, was excreted in the 24 hour urines at the rate of 7-12% to the doses, while thiothiamine showed the excretion of 26-51% to the doses on the similar tests. On the contrary, subcutaneous injection of thiamine in dose of 30mg or 50mg showed its excretion of more than 80% in the urines, while thiothiamine was excreted nearly in the same extent as the oral dosage. Thus it will be reasonably assumed that thiothiamine is more easily permeable through intestinal membranes and the absorbed thiothiamine will be decomposed to a greater extent than thiamine.
日本ビタミン学会の論文