THIOTHIAMINEの生物学的効力について : (II)THIOTHIAMINEの肝臓中における変化および尿への排泄

概要

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Thiothiamine administered to thiamine-deficient albiono rats failed to change itself into thiamine in the liver, and moreover, no transformation of thiothiamine into thiamine could be observed in experiments in which thiothiamine mixed with homogenized livers of various animals was used. Thiothiamine when administered to albino rats, was excreted in much larger amount compared with the case of thiamine. Even when a large amount of thiothiamine was administered, it was never transferred into thiamine, nor would it be accumulated inside the body as thiamine, probably being quickly excreted in urine. From this, it is seen that thiothiamine lacks thiamine activity because it fails to be changed into thiamine inside the body, and probably because, while it is quickly absorbed, it is no less quickly excreted from the body as such, without being accumulated therein.
日本ビタミン学会の論文