酸化性細菌に關する研究 (第3報) : 2-ケトグルコン酸石灰の利用に就て

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For the purpose of utilizing, the reduction product of calcium 2-ketogluconate produced by Pseudomonas in simple synthetic medium as a calcium therapeutic, we carried out the hydrogenation of its aqueous solution under 35 atmospheric pressure and at a temperature between 20〜50℃ by RANEY's nickel or palladium as catalyst.1. The analysis of the brucin salts prepared from the hydrogenated solution and the measurement of optical rotion of the hydrogenated solution, calcium gluconate and calcium mannonate, to which borax is added or not, have shown that the hydrogenation product is a mixture consisting of an equal part of calcium glu-conate and calcium mannonate.2. Solution of this mixture did not crystallize, even so concentrated as to a syrupy state.3. It has been proved by animal test that the hydrogenation product is non-toxic, and can be used as a calsium therapeutic.
社団法人日本生物工学会の論文
1951-12-15