Thiobacillus thiooxidansの生育に対するケト酸の影響

概要

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The growth of the strictly chemoautotrophic bacterium Thiobacillus thiooxidanswas inhibited by various organic acids. The most potent inhibitors among them were a-keto-acid, i.e. pyruvate, a-ketobutyrate, a-ketoisovalerate. These compounds inhibited the growth completely at a concentration of 1 mM. In contrast, the growth was increased two fold by addition of 1 mM a-ketoglutarate. However, no effect could be found with malonate or glyoxylate. The oxidation of sulfur which is an energy source for this bacteriu, was inhibited at pH 3.0 by adding 1 mM pyruvate, whereas it was accelerated by addition of 1 mM a-ketoglutarate, while the effects of these compunds could not be found at pH 7.0. When the cells were preincubated with 1 mM a-ketoglutarate the effect of inhibition by 1 mM pyruvate was considerably decreased. From these date, one of the reasons that the growth of T. thiooxidans is inhibited or accelerated by the organic acids might be attributed to thier effects on the oxidation of sulfur.
社団法人日本生物工学会の論文
1975-11-25