ビタミンEの血液保存効果に関する研究 : (VII)α-Tocopheryl acetateの赤血球還元グルタチオン値, グルタチオン安定性および血液過酸化脂質に及ぼす影響

概要

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The effects of vitamin E on the reduced glutathione (GSH), the GSH stability of erythrocytes and the thiobarbituric acid (TBA) value of whole blood in the preserved blood are reported. Bloods obtained from normal persons were mixed with citrate-phosphate-dextrose (CPD) or ethylenediaminetetraacetate (EDTA) as anticoagulant. Alpha-tocopheryl acetate was added to anticoagulated bloods to make the concentrations of 20 and 50mg%. The two groups without addition of vitamin E and with addition of solvent alone (the added volumes were equivalent to 20 and 50mg% of vitamin E) were served as controls. When the GSH values were compared on the 3 groups stored for 1 and 3 weeks, these of the two control groups were slightly higher than that of the vitamin E added group. However, no detectable difference was observed among the 3 groups stored for 7 weeks. GSH stabilities were decreased on the 3 groups stored for 4 and 7 days, but the decreased ratio of the vitamin E added group was somewhat smaller than those of the controls. The TBA values of the 3 groups were gradually increased by storage, but the vitamin E added group showed partial inhibition on the increased ratio. However, no significant difference was observed among the 3 groups when they were stored for 7 weeks.
日本ビタミン学会の論文
1972-03-25