The Effect of Vitamin E on the Adenosine Diphosphate Induced Platelet Aggregation

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The influence of vitamin E on the adenosine diphosphate (ADP) induced platelet aggregation was studied, and the following results were obtained. In these experiments, the solutions of α-tocopheryl acetate (2.5mg/ml) and α-tocopheryl acetophosphate (2.5mg/ml) were used.1) When 0.5mg of α-tocopheryl acetate was added per 1ml of platelet rich plasma (PRP) 2 hours prior to experiment, it inhibited ADP (which was added 1μg per 1ml of PRP) induced platelet aggregation.2) Addition of 0.15 or 0.3mg of α-tocopheryl acetophosphate per 1ml of PRP just prior to experiment evidently inhibited ADP induced platelet aggregation.3) Addition of 0.1 or 0.2mg of α-tocopheryl acetate per 1ml of PRP rather promoted the platelet aggregation induced by ADP. The same effect was also observed when the solvents of α-tocopheryl acetate solution (equivalent volumes to 0.1, 0.2 and 0.5mg α-tocopheryl acetate) were added.
日本ビタミン学会の論文