アダマンタン骨格を含有する酸アミド類の合成と生理活性について

概要

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The synthesis and physiological activity of acid amides with an adamantyl group. was examined Bromoadamantanes were converted into adamantanecarboxylic acids by cyanidation with copper cyanide, followed by hydrolysis with 60% sulfuric acid. The acids were treated with thionyl chloride to give acid chlorides, and then condensed with N,N-dialkyl amines (dimethylamine, diethylamine, or n-dipropylamine) to the corresponding adamantanecarboxamides. N,N-Dimethyl-2-adamantanecarboxamide (6) at 250g/10a prevented the growth of Elatine triandra in a paddy field. N,N-Dimethyl-1-adamantanecarboxamide (3) had fungicidal activity toward Phytophthora infestans (mont.) de Bary (tomato late blight) and repellent activity to German cockroachs (Blattella germanica) for 5 days. It was evident that these compounds had physiological activity.
社団法人日本農芸化学会の論文
1994-05-01