Skin Protection Effect of Heterocyclic Compounds Synthesized from Trans-Anethole Derivatives

概要

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The phenylpropanoids (1-(2-methoxyphenyl) -2-propanone (1), 1-(3-methoxyphenyl)-2-propanone (2), 1-(4-methoxyphenyl)-2-propanone (3), 2-hydroxypropiophenone (4) and 4-hydroxypropiophenone(5)) were condensed with diols and dithiols, by which we obtained 25 acetals (1a) to (5a), (4d), (5d) thioacetals (1b) to (5b), (1e) to (5e), and (1c) to (5c). These compounds were examined for their potential to use as whitening agents by measuring their anti-tyrosinase activity, superoxide scavenging effects and anti-hyaluronidase activity. The results showed that compounds (3b), (3e), (4e) and (5c) inhibited tyrosinase activity towards both tyrosine and L-DOPA oxidation by more than 80%. Compounds (3c), (3e) and (5c) had stronger superoxide scavenging activity than kojic acid. Overall we found that compound (3e) has greater activity as a cosmetic whitening agent than arbutin and kojic acid used, which are currently used in commercial cosmetics.
近畿大学の論文
2006-12-20