深部培養における炭酸ガスの挙動と発酵生産への関与

概要

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In biotechnology, different culture method are used to produce novel products, but submerged fermentation is still the reliable way to get a large biomass efficiently on a industrial production line. Technology for submerged cultures should be upgraded as well as making cultures more sophisticated. The oxygen transfer rate may be the best means to evaluate the scale-up and optimization of the culture system in submerged fermentation. Also, carbon dioxide should be taken into account as a factor that directly affects on the fermentation process. Oxygen a substrate for aerobic microorganisms, limits the fermentation kinetics, whereas carbon dioxide acts as the acid in the culture liquid and has influences pH and the acid-base equilibrium of the submerged culture with a medium of electrolytes. This study deals with the kinetics of acrbon dioxide evolution in aeration and agitation systems, the behavior of carbon dioxide during product formation, and its various effects on sophisticated pH-stat submerged fermentation.
社団法人日本生物工学会の論文
1987-01-25