A Change in Gastric Mucosal Ascorbic Acid Status with the Formation, Progression, and Recovery of Compound 48/80-induced Acute Gastric Mucosal Lesions in Rats
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概要
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We examined whether gastric mucosal ascorbic acid status changes with the formation, progression, and recovery of acute gastric mucosal lesions in rats treated with compound 48/80, a mast cell degranulator Fasted Wistar rats received a single intraperitoneal injection of compound 48/80 (0 75 mg/kg) Apparent gastric mucosal lesions occurred 0 5 h after compound 48/80 treatment, progressed gastric mucosal lesions were observed at 3 h, and a partial recovery of the progressed lesions was found at 6 h The gastric mucosal concentrations of total and reduced ascorbic acids in compound 48/80-treated rats decreased to approximately 60% of the levels of untreated rats at 3 h after the treatment but the decreased concentrations of total and reduced ascorbic acids were almost completely returned to the levels of untreated rats at 6 h The gastric mucosal concentration of oxidized ascorbic acid in compound 48/80-treated rats showed little change The serum concentrations of total and reduced ascorbic acids m compound 48/80-treated rats increased at 0 5 h after the treatment and further increased at 3 h but the increased concentrations of total and reduced ascorbic acids were almost completely returned to the levels of untreated rats at 6 h The serum concentration of oxidized ascorbic acid in compound 48/80-treated rats increased transiently at 0 5 h after the treatment The hepatic concentrations of total, reduced, and oxidized ascorbic acids in compound 48/80-treated rats increased 3 h after the treatment, but these increases were not observed at 6 h These results indicate that gastric mucosal ascorbic acid status is disrupted with the progression of acute gastric mucosal lesions in rats treated with compound 48/80
著者
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NAKANO Hiroshi
Department of Internal Medicine, Fujita-Gakuen Health University School of Medicine
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OHTA Yoshiji
Department of Chemistry, Fujita Health University School of Medicine
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今井 淑夫
Division Of Pathology National Institute Of Health Sciences
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今井 淑夫
東京工業大学部有機材科工学科
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今井 淑夫
元 東京工業大学工学部有機材料工学科
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Imai Yoichiro
Department Of Clinical Biochemistry Fujita Health University College
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Ohta Yoshiji
Department Of Chemistry School Of Medicine Fujita Health Univeisity
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Ohta Yoshiji
Department Of Biochemistry School Of Medicine Fujita Health University
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KAMIYA Yoshio
Department of Internal Medicine, School of Medicine, Fujita Health University
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ARISAWA Tomiyasu
Department of Internal Medicine, School of Medicine, Fujita Health University
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Nakano Hiroshi
Department Of Clinico-laboratory Diagnostics Nara Medical University
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今井 淑夫
東京工業大学
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Kamiya Yoshio
Department Of Internal Medicine School Of Medicine Fujita Health University
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Kamiya Yoshio
Department Of Industrial Chemistry Science University Of Tokyo
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Arisawa T
Department Of Gastroenterology Kanazawa Medical University
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Nakano Hiroshi
Department Of Anesthesia Okazaki City Hospital
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Nakano Hiroshi
Department Of Internal Medicine School Of Medicine Fujita Health University
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ARISAWA Tomiyasu
Department of Gastroenterology, Kanazawa Medical University
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Kamiya Yoshio
Department of Applied Chemistry Faculty of Engineering The University of Tokyo
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