Effects of Changes in Obesity and Exercise on the Development of Diabetes and Return to Normal Fasting Plasma Glucose Levels at One-Year Follow-up in Middle-Aged Subjects with Impaired Fasting Glucose
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概要
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Objectives : Borderline diabetes, a precursory condition of diabetes, is an important issue in the prevention of diabetes. The aim of the present study was to clarify the effects of one-year changes in obesity and exercise on the development of diabetes or return to normal fasting plasma glucose (FPG) levels among middle-aged people with impaired fasting glucose (IFG) at baseline. Methods : Among those who attended a basic health examination in 1997, we selected 1, 620 subjects who showed impaired fasting glucose (FPG of 110 mg/dl or higher) and had complete data on height, weight and exercise. At the one-year follow-up (in 1998), 1, 099 of those subjects attended a health examination ; FPG, height, weight and exarcise were evaluated for 731 subjects. Subjects were classified into the following three groups, on the basis of changes in FPG during the year between the two examination : developing diabetes (DM), remaining IFG, and returning to normal (WNL). Results : Among those who were initially obese, there was a significant difference in the proportions of DM, IFG and WNL between those with and without improvement in obesity in the year preceding the follow-up (p<0.05). Those with improvement in obesity showed a significantly higher tendency to return to WNL than those without improvement in obesity. Multiple logistic regression analysis showed that those with improvement in obesity had a significantly higher odds ratio (2.17) to return to WNL (p=0.015). Among those who were initially not obese, there was no significant association between changes in obesity and developing DM or returning to WNL. No significant association was observed between changes in exercise and developing DM or returning to WNL. Conclusion : The present findings suggest that, among obese IFG subjects, improvement in obesity is associated with returning to normal plasma glucose. Weight control may be important for the normalization of borderline diabetes.
- 日本衛生学会の論文
著者
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Kawakami Norito
Department Of Mental Health Department Of Psychiatric Nursing Tokyo University Graduate School Of Me
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AOYAMA Hideyasu
Department of Hygiene & Preventive Medicine,Okayama University Medical School
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Aoyama Hideyasu
Department Of Hygiene And Preventive Medicine Okayama University Medical School
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Kawakami N
Okayama Univ. Graduate School Of Medicine And Dentistry Okayama
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Shimizu Shinichi
Department Of Pathology Seirei Hamamatsu General Hospital
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KAWATA Yuichi
Public Health Center
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Kawakami Norito
Department Of Hygiene And Preventive Medicine Okayama University Graduate School Of Medicine And Den
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Shimizu Shinichi
Department Of Hygiene And Preventive Medicine Okayama University Medical School:national Okayama Med
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