Effects of Bovine β-Casein (1-28) and Its Chemically Synthesized Partial Fragments on Proliferative Responses and Immunoglobulin Production in Mouse Spleen Cell Cultures(Food & Nutrition Science)

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概要

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• Effects of bovine β-casein (1-28) having a phosphoserine-rich region (Glu^<14>-SerP-Leu-SerP-SerP-SerP-Glu-Glu^<21>) and its chemically synthesized partial fragments on proliferation of lymphocytes and immunoglobulin production were investigated in mouse spleen cell cultures. The parent fragment 1-28 and all fragments containing SerP-Leu-SerP and/or SerP-SerP-SerP had a significant mitogenic effect, stimulated proliferation of lymphocytes induced by lipopolysaccharide, phytohemagglutinin, or concanavalin A, and increased immunoglobulin (IgG + IgM + IgA) or IgA levels in the cell cultures. In contrast, dephosphorylated β-casein (14-21) and SerP-SerP amide had hardly any immunoregulatory activity. On the other hand, SerP-Leu-SerP amide reacted little with antibodies specific to bovine β-casein (1-28), but β-casein (14-21), and SerP-SerP-SerP amide obviously reacted with the antibody. These results confirm that the immunoregulatory activity of casein phosphopeptides is attributable to SerP-X-SerP, which may well be available as a non-allergic food ingredient having an adjuvant activity for mucosal IgA responses.

• 社団法人日本農芸化学会の論文
• 2001-11-23

著者

• OTANI Hajime

  Integrated Department of Sciences of Functional Foods, Graduate School of Agriculture, Shinshu Unive

• Watanabe Takehito

  Integrated Department Of Sciences Of Functional Foods Graduate School Of Agriculture Shinshu Univers

• Otani Hajime

  Integrated Dep. Of Sciences Of Functional Foods Graduate School Of Agriculture Shinshu Univ.

• Otani Hajime

  信州大学 農研究 機能性食品開発学 専攻

• Tashiro Y

  Meiji Seika Kaisha Ltd. Kanagawa Jpn

• TASHIRO Yasuhito

  New Materials Division, Meiji Seika Kaisha, Ltd.

関連論文

• Stimulatory Effects of Casein Phosphopeptide (CPP-III) on mRNA Expression of Cytokines in Caco-2 Cells
• Stimulatory Effect of a Dietary Casein Phosphopeptide Preparation on the Mucosal IgA Response of Mice to Orally Ingested Lipopolysaccharide from Salmonella typhimurium(Food & Nutrition Science)
• Effects of Bovine β-Casein (1-28) and Its Chemically Synthesized Partial Fragments on Proliferative Responses and Immunoglobulin Production in Mouse Spleen Cell Cultures(Food & Nutrition Science)
• Reduction of allergic symptoms in NC/Jic Jcl mice fed a diet containing casein phosphopeptide preparation, CPP-III
• Effect of β-Casein (1-28) on Proliferative Responses and Secretory Functions of Human Immunocompetent Cell Lines
• Stimulatory Effect of Lactic Acid Bacteria from Commercially Available Nozawana-zuke Pickle on Cytokine Expression by Mouse Spleen Cells
• Antigen-binding and protein G-binding abilities of immunoglobulin G in hyperimmunized cow's milk treated under various conditions

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