Effect of β-Casein (1-28) on Proliferative Responses and Secretory Functions of Human Immunocompetent Cell Lines
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概要
- 論文の詳細を見る
The effect of bovine β-casein (1-28) purified from commercial casein phosphopeptide preparations on human T, B, and monocyte cell lines was evaluated. Beta-casein (1-28) enhanced the proliferation of the following: T cell lines HUT-78, Jurkat Clone E6-1, and MOLT-4; B cell lines BALL, KHM-1B, and U266B1; and monocyte cell lines U937 and HL-60. Moreover, β-casein (1-28) stimulated IgA production by KHM-1B over 96 h of culture. Semiquantitative reverse transcriptional-polymerase chain reaction analysis indicated that β-casein (1-28) enhanced mRNA expression of interleukin (IL)-6 in U266B1 and KHM-1B. These results suggest that β-casein (1-28) exerts a mitogenic effect on human T, B, and monocyte cells, and an IgA-enhancing effect on B cells.
- 社団法人 日本農芸化学会の論文
- 2004-10-23
著者
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Otani Hajime
Integrated Dep. Of Sciences Of Functional Foods Graduate School Of Agriculture Shinshu Univ.
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Kawahara Takeshi
Integrated Department Of Sciences Of Functional Foods Graduate School Of Agriculture Shinshu Univers
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Kawahara Takeshi
Integrated Dep. Of Sciences Of Functional Foods Graduate School Of Agriculture Shinshu Univ.
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KATAYAMA Daisuke
Integrated Department of Sciences of Functional Foods, Graduate School of Agriculture, Shinshu Unive
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Katayama Daisuke
Integrated Department Of Sciences Of Functional Foods Graduate School Of Agriculture Shinshu Univers
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Otani Hajime
Integrated Department Of Sciences Of Functional Foods Graduate School Of Agriculture Shinshu Univers
関連論文
- Stimulatory Effects of Casein Phosphopeptide (CPP-III) on mRNA Expression of Cytokines in Caco-2 Cells
- Stimulatory Effect of a Dietary Casein Phosphopeptide Preparation on the Mucosal IgA Response of Mice to Orally Ingested Lipopolysaccharide from Salmonella typhimurium(Food & Nutrition Science)
- Effects of Bovine β-Casein (1-28) and Its Chemically Synthesized Partial Fragments on Proliferative Responses and Immunoglobulin Production in Mouse Spleen Cell Cultures(Food & Nutrition Science)
- Reduction of allergic symptoms in NC/Jic Jcl mice fed a diet containing casein phosphopeptide preparation, CPP-III
- Characterization of Casein Phosphopeptides from Fermented Milk Products
- Effect of β-Casein (1-28) on Proliferative Responses and Secretory Functions of Human Immunocompetent Cell Lines
- Stimulatory Effect of Lactic Acid Bacteria from Commercially Available Nozawana-zuke Pickle on Cytokine Expression by Mouse Spleen Cells
- Antigen-binding and protein G-binding abilities of immunoglobulin G in hyperimmunized cow's milk treated under various conditions