Stimulatory Effect of Lactic Acid Bacteria from Commercially Available Nozawana-zuke Pickle on Cytokine Expression by Mouse Spleen Cells
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概要
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We investigated the effect of lactic acid bacteria (LAB) isolated from eight samples of commercially available Nozawana-zuke, a traditional Japanese pickle, on cytokine expression by mouse spleen cell cultures. The 12 isolated strains of LAB (Nz1–Nz12), which were identified as genus Lactobacillus or Leuconostoc by the API50CHL test, enhanced the expression of interferon (IFN)-γ with 6 h of culture. Ten of these 12 LAB, particularly Nz8, enhanced interleukin (IL)-12 p40 expression. The actinase E- and Benzonase-treated or untreated cell wall fraction of Nz8 enhanced both IFN-γ and IL-12 p40 expression, while the cell plasma fraction had little effect. In the presence of anti-toll like receptor 4 antibody, the effect of the cell wall fraction of Nz8 was significantly abrogated. These results suggest that some LAB from Nozawana-zuke have a T helper 1-type immunoenhancing effect.
- 社団法人 日本農芸化学会の論文
- 2006-02-23
著者
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Otani Hajime
Integrated Dep. Of Sciences Of Functional Foods Graduate School Of Agriculture Shinshu Univ.
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Kawahara Takeshi
Integrated Dep. Of Sciences Of Functional Foods Graduate School Of Agriculture Shinshu Univ.
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Otani Hajime
Integrated Department Of Sciences Of Functional Foods Graduate School Of Agriculture Shinshu Univers
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Kawahara Takeshi
Integrated Department Of Sciences Of Functional Foods Graduate School Of Agriculture Shinshu Univers
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