Glucoamylase Production of Aspergillus oryzae in Fed-Batch Culture Using a Statistical Regression Model
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概要
- 論文の詳細を見る
Fed-batch culture of Aspergillus oryzae on maltose medium for glucoamylase production was investigated. The specific glucose consumption rate (δ) was used as an indicator of glucoamylase production and for feed rate control. During this fermentation, cell concentration was estimated continuously by the CO_2 evolution rate which was, in turn, used to calculate the optimal feed rate. The statistical regression model was applied for the construction of a feeding strategy for a fed-batch culture. With this model, the feed rate was used as an operating variable while cell concentration and δ were used as the state variables. The optimal feeding profile for the glucoamylase production could be estimated from the predicted results. Glucoamylase production during the fed-batch culture employing δ as an indicator was 34% higher than that obtained by a constant feed rate.
- 社団法人日本生物工学会の論文
- 1994-10-25
著者
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Kishimoto Michimasa
Science University Of Tokyo
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IMAI YASUHIKO
Research and Development Division, Kikkoman Corporation
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SUZUKI MASARU
Research and Development Division, Kikkoman Corporation
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MASAMOTO MANABU
Akashi Technical Institute, Kawasaki Heavy Industries Ltd.,
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NAGAYASU KOUZO
Akashi Technical Institute, Kawasaki Heavy Industries Ltd.,
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Suzuki M
Institute Of Industrial Science University Of Tokyo
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Suzuki M
Kikkoman Corp. Chiba Jpn
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Imai Y
Kikkoman Corp. Chiba Jpn
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Imai Yasuhiko
Research And Development Division Kikkoman Corporation
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Nagayasu Kouzo
Akashi Technical Institute Kawasaki Heavy Industries Ltd.
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Masamoto Manabu
Akashi Technical Institute Kawasaki Heavy Industries Ltd.
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Suzuki Masaru
Research & Development Division Kikkoman Corporation
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