The Effects of Substituents Introduced into 9-Aminoacridine on Frameshift Mutagenicity and DNA Binding Affinity
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概要
- 論文の詳細を見る
Some derivatives of 9-aminoacridine (1) were synthesized, and their frameshift mutagenicity and DNA binding affinity were studied. The introduction of a methyl group into the acridine ring of 1 reduced the mutagenic activity and the intercalative DNA binding affinity, while the introduction of chlorine increased them. Halogenated derivatived of 1 showed higher toxicity against Salmonella typhimurium TA1537.
- 社団法人日本農芸化学会の論文
- 1997-07-23
著者
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Hasegawa Eietsu
Department Of Applied Chemistry Faculty Of Engineering Niigata University
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Omata S
Niigata Univ. Niigata Jpn
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Omata Saburo
Department Of Biocheaistry Faculty Of Science Niigata University
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TOMOSAKA Hideyuki
Department of Chemistry and Materials Science, Gunma National College of Technology
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Anzai K
Department Of Chemistry Faculty Of Science Science University Of Tokyo
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Anzai Kentaro
Department Of Chemistry Faculty Of Science Science University Of Tokyo
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Tomosaka H
Gunma National Coll. Technol. Gunma Jpn
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Tomosaka Hideyuki
Department Of Chemistry And Materials Science Gunma National College Of Technology
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Tomosaka Hideyuki
Department of Biosystem Science, Graduate School of Science and Technology, Niigata University
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