Enhancement of Mutagenic Activity of 9-Aminoacridine by Introducing a Nitro Group into the Molecule
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概要
- 論文の詳細を見る
Mutagenic activity and DNA intercalation were examined for 9-aminoacridine (9-AA) and its deriva-tives. Introduction of a nitro group into the 9-AA molecule was found to enhance the activity enormously as was detected by the Ames test. Acetylation of amino group at 9-position of acridine ring inhibited the intercalation, the frameshift activity disappearing. Rat liver S9 converted 9-AA metabolically to 9-amino-2-hydroxyacridine.
- 社団法人日本農芸化学会の論文
- 1994-08-23
著者
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Omata S
Niigata Univ. Niigata Jpn
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Omata Saburo
Department Of Biocheaistry Faculty Of Science Niigata University
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TOMOSAKA Hideyuki
Department of Chemistry and Materials Science, Gunma National College of Technology
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Anzai K
Department Of Chemistry Faculty Of Science Science University Of Tokyo
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Anzai Kentaro
Department Of Chemistry Faculty Of Science Science University Of Tokyo
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Tomosaka H
Gunma National Coll. Technol. Gunma Jpn
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Tomosaka Hideyuki
Department Of Chemistry And Materials Science Gunma National College Of Technology
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Tomosaka Hideyuki
Department of Biosystem Science, Graduate School of Science and Technology, Niigata University
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