Inhibition of Arachidonate Lipoxygenase Activities by 2-(3, 4-Dihydroxyphenyl) ethanol, a Phenolic Compound from Olives
スポンサーリンク
概要
- 論文の詳細を見る
The effects of olive fruit extract on arachidonic acid lipoxygenase activities were investigated using rat platelets and rat polymorphonuclear leukocytes (PMNL). Olive extract strongly inhibited both 12-lipoxygenase (12-LO) and 5-lipoxygenase (5-LO) activities. One of the compounds responsible for this inhibition was purified and identified as 2-(3, 4-dihydroxyphenyl)ethanol (DPE). DPE inhibited platelet 12-LO activity (IC_<50>, 4.2μM) and PMNL 5-LO activity (IC_<50>, 13μM) but not cyclooxygenase activity in cell-free conditions. It also inhibited 12-LO activity in intact platelets (IC_<50>, 50μM) and reduced leukotriene B_4 production in intact PMNL stimulated by A23187 (IC_<50>, 26μM). The inhibition by DPE of both lipoxygenase activities was stronger than that by oleuropein, caffeic acid, or 7 other related phenolic compounds, especially in intact cells. These results suggest that DPE is a potent specific inhibitor of lipokygenase activities.
- 社団法人日本農芸化学会の論文
- 1997-02-23
著者
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NAGATA Tadahiro
National Food Research Institute, Ministry of Agriculture, Forestry, and Fisheries
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Sekiya Keizo
Shikoku National Agricultural Experiment Station, Ministry of Agriculture, Forestry, and Fisheries
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Sekiya Keizo
Shikoku National Agricultural Experiment Station
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KOHYAMA Noriko
Shikoku National Agricultural Experiment Station
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FUJIMOTO Shin-ichi
Shikoku National Agricultural Experiment Station
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Fujimoto S
Univ. Tokyo Tokyo Jpn
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Kohyama N
Kyoto Univ. Kyoto Jpn
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Nagata Tadahiro
National Food Research Institute
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