Fermentative Production of trans-4-Hydroxy-L-proline by Clonostachys cylindrospora
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概要
- 論文の詳細を見る
Studies were done on fermentative production of hydroxyproline, a useful chiral source of the side chain moiety of carbapenems. Various microorganisms were screened using an automatic screening-robot system, AminoQuant (Hewlett-Packard), and we found that one fungus strain produced 13.8μg/ml of trans-4-hydroxy-L-proline(t-Hyp). The strain was identified as Clonostachys cylindrospora SANK 14591. Addition of L-proline or glycine to the culture medium stimulated the production of t-Hyp by C. cylindrospora. A ^<13>C-NMR study found that L-proline but not glycine was incorporated into t-Hyp.
- 社団法人日本農芸化学会の論文
- 1995-03-23
著者
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HOSOYA Tsuyoshi
Tsukuba Research Laboratories Sankyo Co., Ltd
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SERIZAWA Nobufusa
Biomedical Research Laboratories, Sankyo Co. Ltd.
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Hosoya T
Sankyo Co. Ltd. Tokyo Jpn
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Hosoya Tsuyoshi
Lead Discovery Research Laboratories
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MATSUOKA Tatsuji
Biomedical Research Laboratories, Sankyo Co., Ltd.
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FURUYA Kouhei
Tsukuba Research Laboratories, Sankyo Co., Ltd.
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Hosoya Tsuyoshi
Tsukuba Research Laboratories Sankyo Co. Ltd.
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Furuya K
Sankyo Co. Ltd. Tokyo Jpn
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Furuya Kouhei
Tsukuba Research Laboratories Sankyo Co. Ltd.
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Serizawa N
Biomedical Research Laboratories Sankyo Co. Ltd.
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Serizawa Nobufusa
Biomedical Research Laboratories Sankyo Co. Ltd.
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Matsuoka Tatsuji
Biomedical Research Laboratories Sankyo Co. Ltd.
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